Problem while determining receivers using interface mapping: "SYSTEM FAILURE" during JCo call. Bean SMPP_CALL_JAVA_RUNTIME3 not found

We have a SOAP to PROXY scenario Which is in Production.

We keep getting the Error:

" Problem while determining receivers using interface mapping: "SYSTEM FAILURE" during JCo call. Bean SMPP_CALL_JAVA_RUNTIME3 not found on host XXXXXX, ProgId =AI_RUNTIME_XXX.

We are using Standard Receiver Determination with single receiver without any condition. And no mapping being used in interface determination.

What are all the possible situation where we face such as this issue in Production.